C4BPB antibody

Volume: 100 µg Purification: Immunogen affinity purified Form: liquid Purity: 95% as determined by SDS-PAGE Host: Rabbit Clonality: polyclonal Clone ID: Isotype: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background: This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. Immunogen: complement component 4 binding protein, beta Synonyms: C4b binding protein beta chain, C4BP, C4BPB Observed MW: 40-45 kDa Uniprot ID: P20851 Reactivity: Human, Mouse, Rat Tested Application: ELISA, IHC, WB, IF Recommended dilution: WB: 1: 500 - 1: 2000; IHC: 1: 50 - 1: 100; IF: 1: 50 - 1: 100 Gene ID: 725 Research Area: Immunology