BRAP Monoclonal Antibody

Size : 100 µL Clone Number: Aliases: 3010002G07Rik; BRAP2; BRCA1 associated protein; EC 6.3.2.; Galectin 2 binding protein; IMP; Impedes mitogenic signal propagation; Renal carcinoma antigen NY REN 63; RING finger protein 52; RNF52; zgc: 92894. Product Type: Monoclonal Antibody Immunogen Species: Human UniProt ID: Q7Z569 Immunogen: Purified recombinant human BRAP protein fragments expressed in E.coli. Host: Mouse Reactivity: Human Tested Applications: ELISA,WB;Recommended dilution: WB: 1: 500-1: 5000 Background: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. Clonality: Monoclonal Isotype: IgG1 Purification Method: Affinity purified Conjugate: Non-conjugated Buffer: Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol. Form: Liquid Stroage: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names: BRAP Research Areas: Epigenetics and Nuclear Signaling;Signal transduction